Article
The effects of colony-stimulating factor-1 (CSF-1) on the development of osteoclasts and their expression of tartrate-resistant acid phosphatase (TRAP) in toothless (tl-osteopetrotic) rats.
Critical reviews in eukaryotic gene expression - 1 Jan 2003
Norgård Maria, Marks Sandy C, Reinholt Finn P, Andersson Göran
Abstract excerpt
The osteopetrotic mutation toothless (tl) in the rat is characterized by a limited number of osteoclasts with reduced amounts and/or activity of tartrate-resistant acid phosphatase (TRAP). Treatment of tl/tl mutants with the cytokine colony-stimulating factor (CSF)-1 increases both osteoclast number and enzyme activity, consistent with a loss-of-function mutation in the CSF-1 gene recently detected in this...
Topics
- Acid Phosphatase
- Animals
- Animals, Genetically Modified
- Bone and Bones
- Cathepsin K
- Cathepsins
- Dose-Response Relationship, Drug
- Endocytosis
- Femur
- Immunoblotting
- Immunohistochemistry
- In Situ Hybridization
- Isoenzymes