Abnormalities of phosphoprotein gene expression in three osteopetrotic rat mutations: elevated mRNA transcripts, protein synthesis, and accumulation in bone of mutant animals.

Abstract excerpt

Osteoclast abnormalities that characterize osteopetrosis, a disorder of bone resorption, may derive from aberrant signals from the osteoblast or the bone matrix. In the present studies, both synthesis and the bone matrix content of the major bone phosphoprotein component, osteopontin, were found...

Topics

• Animals
• Bone and Bones
• Gene Expression
• Mutation
• Osteopetrosis
• Osteopontin
• Phosphoproteins
• RNA, Messenger
• Rats
• Rats, Mutant Strains
• Sialoglycoproteins