Article
Perspectives of identity by descent (IBD) mapping in founder populations.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 1995
Te Meerman G J, Van der Meulen M A, Sandkuijl L A
Abstract excerpt
In a founder population patients with a genetic disease are likely to share predisposing genes from a common ancestor. We show that, depending on the distance of the relationship, patients are expected to share extended segments of DNA around the disease gene. Because of the size of the shared segment, a genomic search with DNA markers for such shared segments, identity by descent (IBD) mapping, can efficiently...
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