Article
Detoxification of an aliphatic amine by N-acetylation: experimental and clinical studies.
Biochemistry international - 1 Jul 1991
Berode M
Abstract excerpt
Incubation of serum serpin (alpha-1-antitrypsin) with 5 mM 1,6-diaminohexane causes significant loss of heterozygotic inhibitor activity. While serpin genes have several alleles, the enzyme complex that acetylates the amine to render it suitable for excretion has primarily two phenotype populations, i.e. slow and fast N-acetylators. This study shows that diacetyl-1,6-diaminohexane does not cause in vitro loss of...
Topics
- Acetylation
- Asthma
- Diamines
- Female
- Heterozygote
- Homozygote
- Humans
- Inactivation, Metabolic
- Male
- Phenotype
- Polymorphism, Genetic
- Toluene 2,4-Diisocyanate