Article
Alteration of the CDKN2A gene in pancreatic cancers: Is it a late event in the progression of pancreatic cancer?
International journal of oncology - 1 Oct 1998
Sugimoto Y, Morita R, Hikiji K, Imura G, Ogata Y, Yasuda D, Kono A, Iguchi H
Abstract excerpt
Various genetic changes are involved in progression of various cancers. We examined alterations (deletion, sequence abnormalities, methylation) of the CDKN2A gene in cell lines and tumor tissues of pancreatic cancers. Some alterations of this gene were found in all the 12 cell lines examined. In...
Topics
- Adult
- Aged
- Aged, 80 and over
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Mutational Analysis
- DNA, Neoplasm
- Disease Progression
- Female
- Genes, Tumor Suppressor
- Humans
- Male
- Middle Aged
- Mutation
- Pancreatic Neoplasms
- Tumor Cells, Cultured