Article
Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis.
Receptors & channels - 1 Jan 1995
Singer M S, Oliveira L, Vriend G, Shepherd G M
Abstract excerpt
A family of G-protein-coupled receptors is believed to mediate the recognition of odor molecules. In order to identify potential ligand-binding residues, we have applied correlated mutation analysis to receptor sequences from the rat. This method identifies pairs of sequence positions where residues remain conserved or mutate in tandem, thereby suggesting structural or functional importance. The analysis...
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