Conserved C-terminal motifs in odorant receptors instruct their cell surface expression and cAMP signaling.

Abstract excerpt

The highly individual plasma membrane expression and cAMP signaling of odorant receptors have hampered their ligand assignment and functional characterization in test cell systems. Chaperones have been identified to support the cell surface expression of only a portion of odorant receptors, with mechanisms remaining unclear. The presence of amino acid motifs that might be responsible for odorant receptors'...

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