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Article

The diversity and evolution of cell cycle regulation in alpha-proteobacteria: a comparative genomic analysis.

BMC systems biology - 28 Apr 2010

Brilli Matteo, Fondi Marco, Fani Renato, Mengoni Alessio, Ferri Lorenzo, Bazzicalupo Marco, Biondi Emanuele G

Abstract excerpt

BACKGROUND: In the bacterium Caulobacter crescentus, CtrA coordinates DNA replication, cell division, and polar morphogenesis and is considered the cell cycle master regulator. CtrA activity varies during cell cycle progression and is modulated by phosphorylation, proteolysis and transcriptional control. In a phosphorylated state, CtrA binds specific DNA sequences, regulates the expression of genes involved in...

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Identifiers

PMID: 20426835
DOI: 10.1186/1752-0509-4-52
PMCID: PMC2877005

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Source receipt: pubmed, retrieved 7 Sept 2026.

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