Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.

6 Feb 1996

Abstract excerpt

A pathogenic role for self-reactive cells against the stress protein Hsp60 has been proposed as one of the events leading to autoimmune destruction of pancreatic beta cells in the diabetes of nonobese diabetic (NOD) mice. To examine this hypothesis, we generated transgenic NOD mice carrying a murine Hsp60 transgene driven by the H-2E alpha class II promoter. This would be expected to direct expression of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8577709
DOI: 10.1073/pnas.93.3.1032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.PMID 8577709Read ↗

T cell reactivity to heat shock protein 60 in diabetes-susceptible and genetically protected nonobese diabetic mice is associated with a protective cytokine profile.Semantic proximity Read ↗

Role of autoreactive CD8+ T cells in organ-specific autoimmune diseases: insight from transgenic mouse models.Semantic proximity Read ↗

Autoimmune Intestinal Pathology Induced by hsp60-Specific CD8 T CellsSemantic proximity Read ↗

Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.Semantic proximity Read ↗

Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?Semantic proximity Read ↗

Pathogenic Autoimmunity in Atherosclerosis Evolves from HSP60-Reactive CD4 + T Cells.Semantic proximity Read ↗

Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice.Semantic proximity Read ↗

Autoimmunity to Chaperonins in the Pathogenesis of Arthritis and DiabetesSemantic proximity Read ↗

HSP60: Issues and Insights on Its Therapeutic Use as an Immunoregulatory AgentSemantic proximity Read ↗

Islet amyloid disrupts MHC Class II antigen presentation and protects NOD mice from autoimmune diabetesSemantic proximity Read ↗

Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice.Semantic proximity Read ↗

Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.