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Article

Autoimmunity to Chaperonins in the Pathogenesis of Arthritis and Diabetes

1 Apr 1991

Abstract excerpt

The immunology of the 65 kd heat shock protein (hsp65) is paradoxical. Microbial and mammalian hsp65 molecules are 50% identical in amino acid sequence and immunologically cross-reactive, so microbial hsp65 looks like self; yet hsp65 is a dominant antigen in infection. Immunity to hsp65 can cause autoimmune diabetes in mice and may be related to autoimmune arthritis in rats and humans, so immunity to hsp65 should...

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PMID: 1680347
DOI: 10.1146/annurev.iy.09.040191.003031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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