Deoxyribonuclease II (DNase II) activity is regulated systemically by a single locus in mice.

Abstract excerpt

A survey of inbred strains of mice revealed genetic variation in DNase II activity in the spleen, liver, kidney, lung, heart, coagulating gland and preputial gland. Since DNase II activities in these tissues were closely correlated to each other, systemic regulation of the enzyme was suggested. The inheritance of quantitative variation in the DNase II activity was studied in a test cross using the spleen DNase II...

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