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Serum alkaline phosphatase activity is regulated by a chromosomal region containing the alkaline phosphatase 2 gene (Akp2) in C57BL/6J and DBA/2J mice.

Physiological genomics - 17 Nov 2005

Foreman Jennifer E, Blizard David A, Gerhard Glenn, Mack Holly A, Lang Dean H, Van Nimwegen Kathryn L, Vogler George P, Stout Joseph T, Shihabi Zakariya K, Griffith James W, Lakoski Joan M, McClearn Gerald E, Vandenbergh David J

Abstract excerpt

Quantitative trait locus (QTL) analyses were conducted to identify chromosomal regions that contribute to variability in serum alkaline phosphatase (AP) enzyme activity in mice derived from the C57BL/6J (B6) and DBA/2J (D2) inbred strains. Serum AP was measured in 400 B6D2 F2 mice at 5 mo and 400 B6D2 F2 mice at 15 mo of age that were genotyped at 96 microsatellite markers, and in 19 BXD recombinant inbred (RI)...

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Identifiers

PMID: 16159911
DOI: 10.1152/physiolgenomics.00062.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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