Article
The influence of genetic background on the expression of mutations at the diabetes (db) locus in the mouse. VI: Hepatic malic enzyme activity is associated with diabetes severity.
Metabolism: clinical and experimental - 1 Oct 1992
Coleman D L
Abstract excerpt
The severity of diabetes produced by the mutation diabetes (db) in the mouse is markedly strain-dependent. When the db mutation is maintained in the C57BL/KsJ (BKs) and DBA/2J strains, severe diabetes is observed, whereas when it is maintained in the C57BL/J (B6) inbred background, a mild, well-c...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Diabetes Mellitus, Experimental
- Heterozygote
- Liver
- Malate Dehydrogenase
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Mutant Strains
- Mutation
- Severity of Illness Index