The influence of genetic background on the expression of mutations at the diabetes (db) locus in the mouse. VI: Hepatic malic enzyme activity is associated with diabetes severity.

Abstract excerpt

The severity of diabetes produced by the mutation diabetes (db) in the mouse is markedly strain-dependent. When the db mutation is maintained in the C57BL/KsJ (BKs) and DBA/2J strains, severe diabetes is observed, whereas when it is maintained in the C57BL/J (B6) inbred background, a mild, well-compensated diabetes is observed. Our studies on the regulation of malic enzyme activity showed that both the BKs and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Chromosome Mapping