Influence of HLA-DRB1 genes and the shared epitope on genetic susceptibility to rheumatoid arthritis in Taiwanese.

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Article

Influence of HLA-DRB1 genes and the shared epitope on genetic susceptibility to rheumatoid arthritis in Taiwanese.

The Journal of rheumatology - 1 Apr 2007

Liu Shih-Chia, Chang Tzu-Yang, Lee Yann-Jinn, Chu Chen-Chung, Lin Marie, Chen Zong-Xian, Liu Hsin-Fu, Dang Ching-Wen, Chang Shih-Chuan, Lee Chyou-Shen, Chen Tien-Ling, Huang Chun-Hsiung

Abstract excerpt

OBJECTIVE: To investigate the association of predisposing and protective HLA-DRB1 alleles with rheumatoid arthritis (RA) and its clinical markers in a Taiwanese population. METHODS: A total of 273 patients with RA and 480 healthy controls, all of Taiwanese origin, were genotyped for HLA-DRB1 alleles by polymerase chain reaction and sequence-based typing assays. The associations between RA and HLA-DRB1 alleles and...

Topics

Adult
Aged
Arthritis, Rheumatoid
Base Sequence
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Male
Middle Aged

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Phenotype

Taiwan

Source

Open in PubMed

Identifiers

PMID: 17309132

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