Article
The genotypic distribution of shared-epitope DRB1 alleles suggests a recessive mode of inheritance of the rheumatoid arthritis disease-susceptibility gene.
Arthritis and rheumatism - 1 Dec 1995
Evans T I, Han J, Singh R, Moxley G
Abstract excerpt
OBJECTIVE: To test whether the genotypic distribution of rheumatoid arthritis (RA)-associated DRB1 alleles suggests that the DRB1-associated disease-susceptibility gene has a recessive or additive (dominant) mode of inheritance. METHODS: Caucasian patients with RA and control subjects were recruited from a faculty outpatient practice. DRB1 typing was done by several DNA-based techniques: polymerase chain reaction...
Topics
- Adult
- Aged
- Alleles
- Arthritis, Rheumatoid
- Chi-Square Distribution
- Disease Susceptibility
- Epitopes
- Female
- Gene Frequency
- Genes, Recessive
- Genetic Markers
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans