Article
Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16.
American journal of human genetics - 1 Feb 1996
Wijnen J, Khan P M, Vasen H, Menko F, van der Klift H, van den Broek M, van Leeuwen-Cornelisse I, Nagengast F, Meijers-Heijboer E J, Lindhout D, Griffioen G, Cats A, Kleibeuker J, Varesco L, Bertario L, Bisgaard M L, Mohr J, Kolodner R, Fodde R
Abstract excerpt
Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant cancer susceptibility condition. Inherited mutations in at least four DNA mismatch repair genes, hMSH2, hMLH1, hPMS1, and hPMS2, are known to cause HNPCC. In this study we used denaturing gradient gel electrophoresis...
Topics
- Adaptor Proteins, Signal Transducing
- Base Sequence
- Carrier Proteins
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Primers
- DNA Repair
- DNA-Binding Proteins
- Electrophoresis, Polyacrylamide Gel
- Europe