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Article

CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations.

Human genetics - 1 Feb 1996

Maliaka Y K, Chudina A P, Belev N F, Alday P, Bochkov N P, Buerstedde J M

Abstract excerpt

Hereditary nonpolyposis colon cancer (HN-PCC) is an autosomally inherited predisposition to cancer that has recently been linked to defects in the human mismatch repair genes hMSH2 and hMLH1. The identification of the causative mutations in HNPCC families is desirable, since it confirms the diagnosis and allows the carrier status of unaffected relatives at risk to be determined. We report six different new...

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PMID: 8566964
DOI: 10.1007/BF02265276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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