Article
Microsatellite and single nucleotide polymorphisms in the β-globin locus control region-hypersensitive Site 2: SPECIFICITY of Tunisian βs chromosomes.
Hemoglobin - 1 Jan 2012
Ben Mustapha Maha, Moumni Imen, Zorai Amine, Douzi Kaïs, Ghanem Abderraouf, Abbes Salem
Abstract excerpt
The diversity of sickle cell disease severity is attributed to several cis acting factors, among them the single nucleotide polymorphisms (SNPs) and (AT) rich region in the β-locus control region (β-LCR). This contains five DNase I hypersensitive sites (HS) located 6 to 22 kb upstream to the ϵ gene. The most important of these is the HS2 (5' β-LCR-HS2), characterized by the presence of three different SNPs and a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.