Nonisotopic hybridization assay for determination of relative amounts of genotypic human immunodeficiency virus type 1 zidovudine resistance.

doi:10.1128/jcm.33.10.2777-2780.1995

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Article

Nonisotopic hybridization assay for determination of relative amounts of genotypic human immunodeficiency virus type 1 zidovudine resistance.

Journal of clinical microbiology - 1 Oct 1995

Eastman P S, Boyer E, Mole L, Kolberg J, Urdea M, Holodniy M

Abstract excerpt

A nonisotopic hybridization assay for human immunodeficiency virus genotypic zidovudine resistance determination is described. Biotinylated PCR product was hybridized with enzyme-labeled probes for wild-type or resistant mutant sequences and detected colorimetrically or chemiluminescently in a mi...

Topics

Antiviral Agents
Drug Resistance, Microbial
Genotype
HIV Infections
HIV-1
Humans
Luminescent Measurements
Mutation
Nucleic Acid Hybridization
Polymerase Chain Reaction
RNA-Directed DNA Polymerase
Reverse Transcriptase Inhibitors
Sensitivity and Specificity
Zidovudine

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Identifiers

PMID: 8567926
DOI: 10.1128/jcm.33.10.2777-2780.1995
PMCID: PMC228576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8567926-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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