Article
CYP2D6 genotypes in Spanish women with breast cancer.
Cancer letters - 19 Jan 1996
Ladona M G, Abildúa R E, Ladero J M, Román J M, Plaza M A, Agúndez J A, Muñoz J J, Benítez J
Abstract excerpt
Wild type and three mutated alleles of the polymorphic CYP2D6 gene were studied in genomic DNA samples from 187 women with breast carcinoma and 151 healthy women by a mutation-specific polymerase chain reaction. The prevalence of the enzyme-inactivating CYP2D6(B) allele was higher among patients (18.2%) than in controls (11.6%; OR = 1.7; 95% c.i. = 1.14-3.13; P = 0.018). This excess was more marked in...
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