Article
Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system.
The Journal of cell biology - 1 Dec 1995
Takei Y, Harada A, Takeda S, Kobayashi K, Terada S, Noda T, Takahashi T, Hirokawa N
Abstract excerpt
Synapsin I is one of the major synaptic vesicle-associated proteins. Previous experiments implicated its crucial role in synaptogenesis and transmitter release. To better define the role of synapsin I in vivo, we used gene targeting to disrupt the murine synapsin I gene. Mutant mice lacking synap...
Topics
- Animals
- Cerebellum
- Cytoskeleton
- Female
- Hippocampus
- Long-Term Potentiation
- Male
- Mice
- Microscopy, Electron
- Molecular Structure
- Mutation
- Neurons
- Presynaptic Terminals
- Synapsins
- Synaptic Vesicles