Article
A patient-derived cytotoxic T-lymphocyte clone and two peptide-dependent monoclonal antibodies recognize HLA-B27-peptide complexes with low stringency for peptide sequences.
Infection and immunity - 1 Jan 1996
Huang F, Hermann E, Wang J, Cheng X K, Tsai W C, Wen J, Kuipers J G, Kellner H, Ackermann B, Roth G, Williams K M, Yu D K, Raybourne R B
Abstract excerpt
HLA-B27 molecules expressed on the T2 mutant cell line do not have peptides. Such empty HLA-B27 molecules were not recognized by an HLA-B27-restricted cytotoxic T-lymphocyte (CTL) clone (auto-1) derived from synovial fluid. To test for peptide dependency of the clone, B27-T2 cells were incubated with a panel of 48 different peptides. This lack of stringency was compared with that of a peptide-dependent monoclonal...
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