A patient-derived cytotoxic T-lymphocyte clone and two peptide-dependent monoclonal antibodies recognize HLA-B27-peptide complexes with low stringency for peptide sequences.

doi:10.1128/iai.64.1.120-127.1996

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Article

A patient-derived cytotoxic T-lymphocyte clone and two peptide-dependent monoclonal antibodies recognize HLA-B27-peptide complexes with low stringency for peptide sequences.

Infection and immunity - 1 Jan 1996

Huang F, Hermann E, Wang J, Cheng X K, Tsai W C, Wen J, Kuipers J G, Kellner H, Ackermann B, Roth G, Williams K M, Yu D K, Raybourne R B

Abstract excerpt

HLA-B27 molecules expressed on the T2 mutant cell line do not have peptides. Such empty HLA-B27 molecules were not recognized by an HLA-B27-restricted cytotoxic T-lymphocyte (CTL) clone (auto-1) derived from synovial fluid. To test for peptide dependency of the clone, B27-T2 cells were incubated...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibody Specificity
Base Sequence
Clone Cells
Cytotoxicity, Immunologic
Flow Cytometry
HLA-B27 Antigen
Humans
L Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Oligopeptides

Structure-Activity Relationship

T-Lymphocytes

Transfection

Source

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Identifiers

PMID: 8557329
DOI: 10.1128/iai.64.1.120-127.1996
PMCID: PMC173736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8557329-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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