Article
The same natural ligand is involved in allorecognition of multiple HLA-B27 subtypes by a single T cell clone: role of peptide and the MHC molecule in alloreactivity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1998
Paradela A, García-Peydró M, Vázquez J, Rognan D, López de Castro J A
Abstract excerpt
The human alloreactive CTL clone 27S69, raised against B*2705, cross-reacts with B*2702 and B*2703, but not with B*2701, B*2704, B*2706, or B*2710. Its natural epitope was identified by electrospray/ion trap mass spectrometry, as the proteasome-derived RRFFPYYV octamer. This is the first HLA-B27...
Topics
- Alleles
- Antigen Presentation
- Binding Sites
- Chromatography, High Pressure Liquid
- Clone Cells
- Epitopes
- HLA-B27 Antigen
- Humans
- Ligands
- Models, Molecular
- Oligopeptides
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- T-Lymphocyte Subsets
- T-Lymphocytes, Cytotoxic