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Article

Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.

Human molecular genetics - 1 Jun 2011

Bagheri-Fam Stefan, Argentaro Anthony, Svingen Terje, Combes Alexander N, Sinclair Andrew H, Koopman Peter, Harley Vincent R

Abstract excerpt

X-linked ATR-X (alpha thalassemia, mental retardation, X-linked) syndrome in males is characterized by mental retardation, facial dysmorphism, alpha thalassemia and urogenital abnormalities, including small testes. It is unclear how mutations in the chromatin-remodeling protein ATRX cause these highly specific clinical features, since ATRX is widely expressed during organ development. To investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21427128
DOI: 10.1093/hmg/ddr109

Genes

ATRX
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.PMID 21427128Read ↗

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