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Article

Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells.

Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006

Tsai Meng-Yin, Yeh Shauh-Der, Wang Ruey-Sheng, Yeh Shuyuan, Zhang Caixia, Lin Hung-Yun, Tzeng Chii-Ruey, Chang Chawnshang

Abstract excerpt

Using a Cre-Lox conditional knockout strategy, we generated a germ cell-specific androgen receptor (AR) knockout mouse (G-AR(-/y)) with normal spermatogenesis. Sperm count and motility in epididymis from AR(-/y) mice are similar to that of WT (G-AR(+/y)) mice. Furthermore, fertility tests show there was no difference in fertility, and almost 100% of female pups sired by G-AR(-/y) males younger than 15 weeks...

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Identifiers

PMID: 17142319
DOI: 10.1073/pnas.0608565103
PMCID: PMC1748162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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