Recombination fraction estimate of zero in the presence of apparent recombinants: effects of incomplete penetrance and sporadic cases.

Abstract excerpt

For a fully penetrant trait, apparent recombinants between the trait and marker loci result in an estimate of the recombination fraction theta > 0. Given allowance for reduced penetrance and/or sporadic cases, this no longer need be true. In this short communication, we describe conditions under which theta is estimated to be zero despite the presence of apparent recombinants. We demonstrate that even if a large...

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