Article
Recombination or heterogeneity: is there a second locus for adult polycystic kidney disease?
Journal of medical genetics - 1 Jul 1990
Elles R G, Read A P, Hodgkinson K A, Watters A, Harris R
Abstract excerpt
Twenty-four families with adult onset polycystic kidney disease were typed for markers flanking the PKD1 locus on chromosome 16. The aggregated results gave a significant lod score in favour of linkage to PKD1. Within this group of families two showed unusual features: recombinations, including d...
Topics
- Adolescent
- Adult
- Aged
- Chromosomes, Human, Pair 16
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Humans
- Male
- Middle Aged
- Pedigree
- Polycystic Kidney Diseases
- Polymorphism, Restriction Fragment Length
- Recombination, Genetic