Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart

1 Sept 2000

Abstract excerpt

Myotonic dystrophy (DM) is a multisystemic disorder caused by an inherited CTG repeat expansion which affects three genes encoding the DM protein kinase (DMPK), a homeobox protein Six5 and a protein containing WD repeats. Using a panel of 16 monoclonal antibodies against several different DMPK epitopes we detected DMPK, as a single protein of approximately 80 kDa, only in skeletal muscle, cardiac muscle and, to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Genetic Neurodegenerative Diseases
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10958655
DOI: 10.1093/hmg/9.14.2167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heartPMID 10958655Read ↗

Identification, Tissue-specific Expression, and Subcellular Localization of the 80- and 71-kDa Forms of Myotonic Dystrophy Kinase ProteinSemantic proximity Read ↗

Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy.Semantic proximity Read ↗

Myotonic dystrophy: molecular and cellular consequences of expanded DNA repeats are elusive.Semantic proximity Read ↗

Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice.Semantic proximity Read ↗

Overexpression of myotonic dystrophy kinase in BC3H1 cells induces the skeletal muscle phenotype.Semantic proximity Read ↗

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.Semantic proximity Read ↗

Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization.Semantic proximity Read ↗

Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence.Semantic proximity Read ↗

Development and Application of a Cell-Based Assay for LRP4 Antibody Associated With Myasthenia GravisSemantic proximity Read ↗

Epitope Mapping of DhMab-1: An Antidiacylglycerol Kinase Monoclonal Antibody.Semantic proximity Read ↗

Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines.Semantic proximity Read ↗

Developmental expression of myotonic dystrophy protein kinase in brain and its relevance to clinical phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.