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Article

Activation of the MEF2 transcription factor in skeletal muscles from myotonic mice.

The Journal of clinical investigation - 1 May 2002

Wu Hai, Olson Eric N

Abstract excerpt

Becker syndrome, a recessive nondystrophic myotonia caused by mutations in the chloride channel 1 gene (CLCN1), is characterized by delayed muscle relaxation after contraction. The ADR (arrested development of righting response) mouse is an animal model for Becker syndrome. Skeletal muscles from ADR myotonic animals show an increased number of oxidative fibers with a lack of glycolytic fibers as well as signs of...

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Share to Chloride Channels
Share to MEF2 Transcription Factors
Share to Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Myogenic Regulatory Factors

Share to Myotonia Congenita

Share to p38 Mitogen-Activated Protein Kinases

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 12021248
DOI: 10.1172/JCI15417
PMCID: PMC150985

Genes

CLCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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