Article
The response to thrombin of human neutrophils: evidence for two novel receptors.
Journal of cell science - 1 Sept 1995
Jenkins A L, Howells G L, Scott E, Le Bonniec B F, Curtis M A, Stone S R
Abstract excerpt
Human alpha-thrombin was a chemoattractant for human neutrophils yielding a maximal response of similar magnitude to that observed with formyl-Met-Leu-Phe. The observed chemotaxis was not due to stimulation of the proteolytically activated thrombin receptor since: (1) this receptor was not detected by flow cytometry; (2) the inactive thrombin mutant Ser195-->Ala elicited a chemotactic response indistinguishable...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.