Article
Linking distant relatives with BRCA gene mutations: potential for cost savings.
Clinical genetics - 1 Jan 2014
Senter L, O'Connor M, Oriyo F, Sweet K, Toland A E
Abstract excerpt
Thousands of individuals have undergone mutational analysis of BRCA1 and BRCA2. The Ohio State University Clinical Cancer Genetics program has identified 466 individuals from 289 families with a mutation in BRCA1 or BRCA2. Excluding Ashkenazi Jewish founder mutations, we observed 9 deleterious BRCA mutations five or more times in ostensibly unrelated families and another 13 mutations in 3-4 families. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.