Article
Mutant p53: the loaded gun.
Current opinion in investigational drugs (London, England : 2000) - 1 Aug 2001
Selivanova G
Abstract excerpt
Alterations in the p53 gene are the most common genetic defects found in tumors so far. Taking into account that p53 is a powerful inducer of cell death it is not surprising that the abolition of its function occurs almost universally during tumor development. There are several features of p53 inactivation in tumors which are quite unique. Firstly, mutations occur at high frequency in the p53 gene, ie, around 50%...
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