Article
Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene.
Nature genetics - 1 Jan 1997
Gayther S A, Mangion J, Russell P, Seal S, Barfoot R, Ponder B A, Stratton M R, Easton D
Abstract excerpt
The breast cancer susceptibility gene BRCA2 on chromosome 13q12-13 has recently been identified. Germline mutations of BRCA2 are predicted to account for approximately 35% of families with multiple case, early onset female breast cancer, and they are also associated with an increased risk of male...
Topics
- BRCA2 Protein
- Breast Neoplasms
- DNA Mutational Analysis
- Female
- Frameshift Mutation
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Male
- Neoplasm Proteins
- Ovarian Neoplasms
- Risk Factors