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Article

N-linked glycan modifications in gp120 of human immunodeficiency virus type 1 subtype C render partial sensitivity to 2G12 antibody neutralization.

Journal of virology - 1 Oct 2007

Gray Elin S, Moore Penny L, Pantophlet Ralph A, Morris Lynn

Abstract excerpt

The monoclonal antibody (MAb) 2G12 recognizes a cluster of high-mannose oligosaccharides on the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 and is one of a select group of MAbs with broad neutralizing activity. However, subtype C viruses are generally resistant to 2G12 neutralization. This has been attributed to the absence of a glycosylation site at position 295 in most subtype C...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Antibodies, Viral
Binding Sites, Antibody
Epitopes
Glycosylation
HIV Envelope Protein gp120
HIV-1
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Polysaccharides

Protein Conformation

Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 17634239
DOI: 10.1128/JVI.01106-07
PMCID: PMC2045459

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