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Article

Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases.

Essays in biochemistry - 1 Jan 1998

Lunkes A, Trottier Y, Mandel J L

Abstract excerpt

HD is an autosomal dominant neurodegenerative disorder characterized by involuntary movements, cognitive impairment progressing to dementia, and mood disturbances. The brains of patients show extensive neuronal loss in the striatum, and the cerebral cortex is also affected. The genetic defect cau...

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Identifiers

PMID: 10488448
DOI: 10.1042/bse0330149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10488448-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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