Article
Genetics and molecular biology of Huntington's disease.
Trends in neurosciences - 1 Jan 1995
Albin R L, Tagle D A
Abstract excerpt
In 1993, the genetic abnormality responsible for Huntington's disease was identified as a trinucleotide-repeat expansion in a novel gene. Much has been learned about the molecular genetics of Huntington's disease and the possible effects of the trinucleotide expansion in the development of this disease and other neurological disorders. The Huntington's disease locus is widely expressed throughout the brain and in...
Topics
- Alleles
- Chromosome Mapping
- Gene Expression Regulation
- Humans
- Huntington Disease
- Molecular Biology
- Nerve Degeneration
- RNA, Messenger
- Repetitive Sequences, Nucleic Acid