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Article

Huntington's disease.

Seminars in cell biology - 1 Feb 1995

Gusella J F, MacDonald M E

Abstract excerpt

Early in 1993, an unstable, expanded trinucleotide repeat in a novel gene of unknown function was identified on HD chromosomes. This discovery unleased a flurry of experimentation that has established the expanded CAG repeat the almost universal cause of the characteristic neurologic symptoms and pathology of this neurodegenerative disorder of midlife onset. The biochemical basis for the specific neuronal loss of...

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PMID: 7620118
DOI: 10.1016/1043-4682(95)90011-x

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