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Article

Huntington's disease: CAG genetics expands neurobiology.

Current opinion in neurobiology - 1 Oct 1995

Gusella J F, MacDonald M E

Abstract excerpt

Huntington's disease, with its progressive uncontrolled movements and characteristic selective neuropathology, has represented a baffling enigma to geneticists and neurobiologists alike. Discovery of the HD gene and its defect has demystified the genetic aspects of the disorder, but has not yet explained its pathogenesis. Attempts to explore this issue suggest that the defect acts as a gain of function,...

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PMID: 8580718
DOI: 10.1016/0959-4388(95)80072-7

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