Article
Mutation of the gene for the human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease.
Neuroscience letters - 2 Apr 1993
Wong L, Liang Y, Jiang L, Tsuda T, Fong Q, Galway G, Alexandrova N, Rogaeva E, Lukiw W, Smith J
Abstract excerpt
Recent genetic linkage studies have implicated a gene on chromosome 14 in the pathogenesis of FAD. The identity of this gene remains unknown but it has been speculated that it may be involved in the cellular processing of the amyloid precursor protein (APP). We have analyzed the nucleotide sequence of the entire open reading frame of the cathepsin G gene located on chromosome 14q. No mutations were observed,...
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