Article
Disulfide Bond Pattern of Transforming Growth Factor β-Induced Protein.
Biochemistry - 4 Oct 2016
Lukassen Marie V, Scavenius Carsten, Thøgersen Ida B, Enghild Jan J
Abstract excerpt
Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein composed of an NH2-terminal cysteine-rich domain (CRD) annotated as an emilin (EMI) domain and four fasciclin-1 (FAS1-1-FAS1-4) domains. Mutations in the gene cause corneal dystrophies, a group of debilitating protein misfolding diseases that lead to severe visual impairment. Previous studies have shown that TGFBIp in the...
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