Article
Interaction of Trypanosoma cruzi with cells with altered glycosylation patterns.
Biochemical and biophysical research communications - 15 Jun 1993
Ciavaglia M do C, de Carvalho T U, de Souza W
Abstract excerpt
Glycosylation mutants of chinese hamster ovary cells were used to analyse the role played by surface-exposed carbohydrates on the process of interaction of Trypanosoma cruzi with the host cell. Adhesion and invasion of the parasites were markedly reduced in cells which express very few sialic acid residues. Infection levels similar to those obtained with the parental cell could be obtained after sialylation of...
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