Article
Involvement of host cell heparan sulfate proteoglycan in Trypanosoma cruzi amastigote attachment and invasion.
Parasitology - 1 Apr 2011
Bambino-Medeiros R, Oliveira F O R, Calvet C M, Vicente D, Toma L, Krieger M A, Meirelles M N, Pereira M C S
Abstract excerpt
Cell surface glycosaminoglycans (GAGs) play an important role in the attachment and invasion process of a variety of intracellular pathogens. We have previously demonstrated that heparan sulfate proteoglycans (HSPG) mediate the invasion of trypomastigote forms of Trypanosoma cruzi in cardiomyocytes. Herein, we analysed whether GAGs are also implicated in amastigote invasion. Competition assays with soluble GAGs...
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