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Article

Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment.

The Journal of cell biology - 1 Jun 1993

Vida T A, Huyer G, Emr S D

Abstract excerpt

We are studying intercompartmental protein transport to the yeast lysosome-like vacuole with a reconstitution assay using permeabilized spheroplasts that measures, in an ATP and cytosol dependent reaction, vacuolar delivery and proteolytic maturation of the Golgi-modified precursor forms of vacuolar hydrolases like carboxypeptidase Y (CPY). To identify the potential donor compartment in this assay, we used...

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Identifiers

PMID: 8509446
DOI: 10.1083/jcb.121.6.1245
PMCID: PMC2119698

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Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment.PMID 8509446Read ↗

In vitro reconstitution of intercompartmental protein transport to the yeast vacuole.Semantic proximity Read ↗

Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.Semantic proximity Read ↗

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Semantic proximity Read ↗

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Retention of a co-translational translocated mutant protein of carboxypeptidase Y of Saccharomyces cerevisiae in endoplasmic reticulum.Semantic proximity Read ↗

Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism.Semantic proximity Read ↗

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.Semantic proximity Read ↗

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