Article
A highly polymorphic microsatellite in the class II Eb gene allows tracing of major histocompatibility complex evolution in mouse.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1993
Saha B K, Shields J J, Miller R D, Hansen T H, Shreffler D C
Abstract excerpt
A hallmark of major histocompatibility complex (MHC) genes is their extraordinarily high level of polymorphism. Polymorphic residues on MHC molecules determine which peptide ligands they bind and present to effector T lymphocytes. Although the genetic mechanisms responsible for MHC polymorphism have been delineated, the timetable and the pathway of their diversification remain unclear. To trace MHC evolution, we...
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