Article
Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF7 breast cancer cells.
The Journal of steroid biochemistry and molecular biology - 1 Apr 1993
Koehorst S G, Jacobs H M, Thijssen J H, Blankenstein M A
Abstract excerpt
Human meningiomas are rich in progesterone receptors (PR), which appear to be expressed autonomously. To investigate whether estrogen receptor (ER) variants which do not bind the ligand, but may constitutively induce PR expression, prevail in meningioma, we amplified cDNA by PCR in order to detec...
Topics
- Alternative Splicing
- Base Sequence
- Binding Sites
- Breast Neoplasms
- DNA
- Exons
- Humans
- Meningioma
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- RNA, Neoplasm
- Receptors, Estrogen
- Sequence Analysis, DNA
- Transcription, Genetic
- Tumor Cells, Cultured