Article
Aberrant oestrogen receptor species in human meningioma tissue.
The Journal of steroid biochemistry and molecular biology - 1 Sept 1992
Koehorst S G, Jacobs H M, Tilanus M G, Bouwens A G, Thijssen J H, Blankenstein M A
Abstract excerpt
Meningiomas are very rich in progestin receptors (PR) whereas oestrogen receptors (ER) are seldomly found and only at low concentrations. These tumours might possess an ER which is defective in oestrogen binding but still functional in stimulating oestrogen-responsive genes such as PR. In human meningiomas a polymerase chain reaction fragment including the DNA binding domain, the hinge region and the ligand...
Topics
- Base Sequence
- DNA, Neoplasm
- Exons
- Humans
- Meningeal Neoplasms
- Meningioma
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Receptors, Estrogen
- Receptors, Progesterone