RAS/RAF landscape in monoclonal plasma cell conditions.

doi:10.1182/blood.2023022295

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Article

RAS/RAF landscape in monoclonal plasma cell conditions.

Blood - 11 Jul 2024

Schavgoulidze Anais, Corre Jill, Samur Mehmet Kemal, Mazzotti Celine, Pavageau Luka, Perrot Aurore, Cazaubiel Titouan, Leleu Xavier, Macro Margaret, Belhadj Karim, Roussel Murielle, Brechignac Sabine, Montes Lydia, Caillot Denis, Frenzel Laurent, Rey Philippe, Schiano de Colella Jean-Marc, Chalopin Thomas, Jacquet Caroline, Richez Valentine, Orsini-Piocelle Frederique, Fontan Jean, Manier Salomon, Martinet Ludovic, Sciambi Adam, Mohty Mohamad, Avet-Loiseau Herve

Abstract excerpt

ABSTRACT: Multiple myeloma is characterized by a huge heterogeneity at the molecular level. The RAS/RAF pathway is the most frequently mutated, in ∼50% of the patients. However, these mutations are frequently subclonal, suggesting a secondary event. Because these genes are part of our routine next-generation sequencing panel, we analyzed >10 000 patients with different plasma cell disorders to describe the...

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Identifiers

PMID: 38643494
DOI: 10.1182/blood.2023022295
PMCID: PMC11451330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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