Article
Genetics of LDL subclass phenotypes in women twins. Concordance, heritability, and commingling analysis.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 May 1993
Austin M A, Newman B, Selby J V, Edwards K, Mayer E J, Krauss R M
Abstract excerpt
Low density lipoprotein (LDL) subclass phenotype B, characterized by a predominance of small LDL as determined by gradient gel electrophoresis, has been associated with increased risk of coronary heart disease and an atherogenic lipoprotein profile. Previous studies employing complex segregation analysis have demonstrated a major, single gene effect on the inheritance of this phenotype in families. Recently,...
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