Article
Microsatellite instability in cancer of the proximal colon.
Science (New York, N.Y.) - 7 May 1993
Thibodeau S N, Bren G, Schaid D
Abstract excerpt
Colorectal tumor DNA was examined for somatic instability at (CA)n repeats on human chromosomes 5q, 15q, 17p, and 18q. Differences between tumor and normal DNA were detected in 25 of the 90 (28 percent) tumors examined. This instability appeared as either a substantial change in repeat length (often heterogeneous in nature) or a minor change (typically two base pairs). Microsatellite instability was significantly...
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