Microsatellite instability in cancer of the proximal colon.

doi:10.1126/science.8484122

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Article

Microsatellite instability in cancer of the proximal colon.

Science (New York, N.Y.) - 7 May 1993

Thibodeau S N, Bren G, Schaid D

Abstract excerpt

Colorectal tumor DNA was examined for somatic instability at (CA)n repeats on human chromosomes 5q, 15q, 17p, and 18q. Differences between tumor and normal DNA were detected in 25 of the 90 (28 percent) tumors examined. This instability appeared as either a substantial change in repeat length (of...

Topics

Adult
Aged
Aged, 80 and over
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 5
Colonic Neoplasms
Colorectal Neoplasms
DNA, Neoplasm
DNA, Satellite
Female
Heterozygote
Humans
Male
Middle Aged
Mutation
Polymerase Chain Reaction

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