Article
The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1993
Pannetier C, Cochet M, Darche S, Casrouge A, Zöller M, Kourilsky P
Abstract excerpt
A method using PCR amplification and primer extension with fluorescent oligonucleotides was developed to analyze T-cell repertoires. The sizes of the hypervariable CDR3-like regions of the murine T-cell antigen receptor beta chains were measured for all possible V beta-J beta combinations. This analysis shows that beta chains are distributed into at least 2000 groups, a value that provides a lower limit to their...
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